Radial artery tonometry demonstrates arterial stiffness in children with type 1 diabetes.

NOS3 polymorphisms are associated with arterial stiffness in children with type 1 diabetes.

OBJECTIVE Type 1 diabetes is associated with endothelial dysfunction, arterial stiffness, and an increased risk of cardiovascular disease (CVD) events. We previously demonstrated increased arterial stiffness in children with type 1 diabetes compared with control subjects. However, traditional CVD risk factors did not explain the difference in arterial stiffness. Furthermore, children with type ...

Serum Monocyte Chemoattractant Protein-1 Concentrations Associate With Diabetes Status but Not Arterial Stiffness in Children With Type 1 Diabetes

OBJECTIVE The relationship between circulating markers of inflammation and arterial stiffness in children with type 1 diabetes is not well studied. We tested whether inflammatory monocyte chemoattractant protein (MCP)-1 concentrations correlate with arterial stiffness or type 1 diabetes status. RESEARCH DESIGN AND METHODS MCP-1 concentrations and radial tonometry data were available for 98 ch...

Correlation between radial artery tonometry- and fingertip tonometry-derived augmentation index in children with type 1 diabetes.

DPP-4 Inhibitor Reduces Central Blood Pressure in a Diabetic and Hypertensive Patient

Hypertension and type 2 diabetes mellitus (DM) are among the main risk factors for the development of cardiovascular disease. Pharmacotherapy for DM should not only improve blood glucose control, but also provide beneficial glucose-independent cardiovascular effects. The central systolic blood pressure (SBP) has become more important than the brachial SBP in the assessment of cardiovascular ris...

Insulin-induced decrease in large artery stiffness is impaired in uncomplicated type 1 diabetes mellitus.

Normal insulin action in vivo involves a decrease in stiffness of large arteries (a decrease in aortic pressure augmentation). We determined whether the ability of insulin to decrease arterial stiffness is altered in uncomplicated type 1 diabetes. Nine type 1 diabetic men (age 28+/-2 years, body mass index 24+/-1 kg/m(2)) and 9 matched normal men were studied under normoglycemic hyperinsulinemi...